Research progress of lncRNA regulating miRNA in osteoarthritis
10.3760/cma.j.cn101721-20210907-000126
- VernacularTitle:lncRNA调控miRNA在骨关节炎中的研究进展
- Author:
Jichao BIAN
1
;
Li WANG
;
Xiaopeng ZHOU
;
Bingliang LI
;
Zhimeng WANG
;
Long YUAN
;
Sen LI
;
Yuanmin ZHANG
;
Guodong WANG
Author Information
1. 济宁医学院临床医学院，济宁 272067
- Keywords:
Osteoarthritis;
Long non-coding RNAs;
MicroRNA
- From:
Clinical Medicine of China
2022;38(2):183-187
- CountryChina
- Language:Chinese
-
Abstract:
Non-coding RNAs (ncRNAs), which are thought to regulate articular cartilage through endochondral osteogenesis, consist of mRNA-interfering complementary RNA (miRNA) and long non-coding RNAs (lncRNA). More and more experimental evidence reveals the role of ncRNAs in chondrocyte differentiation and the pathogenesis of several skeletal diseases, including osteoarthritis. In the past few years, increasingly sophisticated DNA sequencing methods and a large number of sepigenetic modifications have greatly contributed to our understanding of the pathophysiological mechanisms of osteoarthritis. Recent studies have revealed that RNA interacts with RNA-binding proteins, regulates gene transcription and protein translation, and is involved in various pathological processes in OA, promising to be a therapeutic target for osteoarthritis.
