Clinical characteristics and prognosis of pregnancy complicated with pheochromocytoma/paraganglioma
10.3760/cma.j.cn101721-20210705-000005
- VernacularTitle:妊娠合并嗜铬细胞瘤/副神经节瘤5例临床特征及预后分析
- Author:
Yun LI
1
;
Na LI
;
Ning GUO
;
Longmin LI
;
Haichun LIU
;
Hongbo GAO
;
Xiaoyong ZHANG
;
Yujun SHAO
Author Information
1. 北京核工业医院核素诊疗中心，北京 102413
- Keywords:
Pregnancy;
Pheochromocytoma;
Paraganglioma;
Clinical features;
Prognosis
- From:
Clinical Medicine of China
2022;38(1):24-29
- CountryChina
- Language:Chinese
-
Abstract:
Pheochromocytoma/paraganglioma is an adrenal tumor that secrets catecholamines and is extremely rare in pregnant women. Its clinical presentation is lack of specificity, and the combination of low prevalence and nonspecific clinical presentation makes diagnosis and treatment difficult. In this study, the clinical data and prognosis of 5 pregnant patients with pheochromocytoma/paraganglioma were analyzed. It was found that hypertension first occurred in 4 patients during pregnancy, and the clinical manifestations of each case were different. Surgical treatment is the first choice in the treatment, patients who cannot operate can choose radionuclide therapy, chemotherapy and targeted therapy. Through follow-up, they all showed recurrence and metastasis at different times. Among them, the patients who continued to be pregnant to the middle and late stages of surgical treatment progressed rapidly, and there were multiple bone metastases throughout the body in a short period of time, and two cases died in a short period of time. Therefore, effective diagnosis, individualized treatment and lifelong follow-up are particularly important.
