A Case of Buschke-Lowenstein Tumor That Progressed to Squamous Cell Carcinoma.
- Author:
Tae Hyun KIM
1
;
Hyung Jin AHN
;
Eung Ho CHOI
;
Won Soo LEE
;
Sang Min HWANG
;
Sung Ku AHN
Author Information
1. Department of Dermatology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
- Publication Type:Case Report
- Keywords:
Buschke-Lowenstein tumor;
Squamous cell carcinoma;
HPV 6;
p53
- MeSH:
Buschke-Lowenstein Tumor*;
Carcinoma, Squamous Cell*;
Circumcision, Male;
Female;
Human papillomavirus 6;
Humans;
Hygiene;
Immunosuppression;
Male;
Penis;
Smell;
Ulcer
- From:Korean Journal of Dermatology
2000;38(6):789-792
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Buschke-Lowenstein (B-L) tumor occurs in penis associated with human papillomavirus (HPV). It appears as a exophytic cauliflower-like mass that may be foul smelling and sometimes ulcerated. B-L tumor is predominantly associated with HPV 6, 11 and rarely 16, 18. Because HPV 6, 11 are usually isolated from benign lesions, it has been hypothesized that other cofactors such as immunosuppression, poor hygiene, lack of circumcision, and chronic irritation may be involved. In addition, genomic alternation or subtle amino-acid changes in the HPV 6 E7 protein may play a role in enhancing oncogenic properties of the low-risk virus, HPV 6. We present a case of B-L tumor with squamous cell carcinoma that showed HPV 6 positive and altered p53.
