Correlation between thromboelastography and portal vein thrombosis in patients with cirrhotic esophagogastric varices
10.3760/cma.j.cn431274-20220419-00359
- VernacularTitle:肝硬化食管胃静脉曲张患者中血栓弹力图与门静脉血栓相关性研究
- Author:
Chunyan XUE
1
;
Siyu JIANG
;
Ling WU
;
Chenyi RAO
;
Xiaoquan HUANG
;
Feng LI
Author Information
1. 复旦大学附属中山医院消化科，上海 200032
- Keywords:
Esophageal and gastric varices;
Liver cirrhosis;
Thrombelastography;
Portal vein thrombosis
- From:
Journal of Chinese Physician
2022;24(5):649-652,657
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between thromboelastography (TEG) and portal vein thrombosis in patients with cirrhotic esophagogastric varices.Methods:210 hospitalized patients with cirrhotic esophagogastric varices treated in Zhongshan Hospital Affiliated to Fudan University from December 2016 to December 2017 were retrospectively included. They were divided into portal vein thrombosis group (PVT group) and non portal vein thrombosis group (NPVT group) according to whether they were complicated with portal vein thrombosis. The correlation between the results of TEG coagulation reaction time (R value), coagulation time (K value), αAngle, maximum amplitude (MA) and coagulation composite index (CI) and portal vein thrombosis was analyzed. The characteristics of coagulation status in patients with portal vein thrombosis in cirrhosis were compared.Results:A total of 91 patients (43.3%) were complicated with portal vein thrombosis. The R value in the PVT group was significantly lower than that of NPVT group [5.49(5.22-5.77) vs 5.98(5.76-6.20), P=0.006]. Logistic regression analysis showed that Child Pugh grade ( OR=2.883, 95% CI: 1.630-5.098, P<0.001) and R value ( OR=0.739, 95% CI: 0.575-0.950, P=0.018) were independently associated risk factors of PVT. The R value of patients was significantly correlated with Child Pugh grade ( r=0.147, P=0.034), platelet ( r=-0.358, P<0.001), prothrombin time (PT) ( r=0.334, P<0.001) and international standardized ratio (INR) ( r=0.328, P<0.001). Conclusions:The decrease of TEG-R value is closely related to PVT in liver cirrhosis.
