Research progress on the relationship between steroid-induced avascular necrosis of the femoral head and microRNA
10.3760/cma.j.cn431274-20210517-00554
- VernacularTitle:激素性股骨头坏死与miRNA关系的研究进展
- Author:
Zhaofeng SUN
1
;
Guodong WANG
;
Haiyi ZHENG
;
Long YUAN
;
Yuanmin ZHANG
Author Information
1. 济宁医学院临床医学院，济宁 272067
- Keywords:
miRNA;
Signaling pathway;
Steroid-induced avascular necrosis of the femoral head
- From:
Journal of Chinese Physician
2022;24(4):626-630
- CountryChina
- Language:Chinese
-
Abstract:
Steroid-induced avascular necrosis of the femoral head (SANFH) is the death of the femoral head caused by long-term use of glucocorticoid (GC). Its pathological manifestations are mainly trabecular bone collapse and increased empty bone lacunas, osteocyte apoptosis rate and autophagy rate. Its pathogenesis is complicated, and the exact pathogenesis is still unclear. MicroRNAs (miRNAs) are a group of endogenous, non-coding small RNAs with an average length of 23 nucleotides. They are responsible for negatively regulating gene expression after transcription by inhibiting target messenger RNAs (mRNAs). MiRNAs play an important role in physiological processes, including cell development, proliferation, differentiation, metabolism, migration and apoptosis. According to bioinformatics analysis, MiRNAs play an important role in regulating gene expression, and it is estimated that more than one-third of human genes are regulated by them. In the past few years, more and more miRNAs have been found to be related to osteonecrosis, such as regulating the proliferation and differentiation of mesenchymal stem cells and osteoblasts. This article aims to review the relationship between steroid-induced femoral head necrosis and miRNAs.
