Research progress and safety of immune checkpoint inhibitors in the treatment of gastrointestinal neoplasms
10.3760/cma.j.cn431274-20220221-00121
- VernacularTitle:免疫检查点抑制剂在胃肠道肿瘤治疗的研究进展及安全性探讨
- Author:
Yixiang ZHUANG
1
;
Gaofeng LIN
;
Guoxi XU
;
Huaishuai WANG
;
Zhicong CAI
;
Yinlin LI
;
Qiyi LIN
;
Weibo LIU
Author Information
1. 晋江市医院胃肠外科，泉州 362200
- Keywords:
Gastrointestinal neoplasms;
Immune checkpoint inhibitor;
Programmed cell death 1 receptor;
Microsatellite instability
- From:
Journal of Chinese Physician
2022;24(3):338-340,345
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal neoplasms is the most common digestive tract neoplasms, and its incidence rate is increasing year by year. Compared with other solid tumors, the application of immune checkpoint inhibitors in gastrointestinal neoplasms is still in the stage of continuous exploration. This paper intends to review the relevant research and latest progress of immune checkpoint inhibitors in advanced gastric cancer, mismatch repair function defect/microsatellite high instability and mismatch repair function integrity/microsatellite stability or microsatellite low instability, and further evaluate the effectiveness and safety of immunotherapy combined with relevant studies.
