The clinical heterogeneity of diabetes challenges the accuracy of typing diagnosis
10.3760/cma.j.cn431274-20220124-00059
- VernacularTitle:糖尿病的临床异质性对精准分型诊断的挑战
- Author:
Shuoming LUO
1
;
Zhiguang ZHOU
Author Information
1. 中南大学湘雅二医院代谢内分泌科，糖尿病免疫学教育部重点实验室，国家代谢性疾病临床医学研究中心，长沙 410011
- Keywords:
Diabetes mellitus;
Heterogeneity;
Precision medicine;
Typing diagnosis
- From:
Journal of Chinese Physician
2022;24(2):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a group of clinical syndromes with multiple causes and pathologies resulting from multiple factors. Different types of diabetes have different intrinsic types and complex clinical phenotypes according to genetics, immunology, metabolism, and clinical characteristics. Latent autoimmune diabetes in adults and ketosis-prone diabetes are the manifestation of clinical heterogeneity among different types of diabetes. High clinical heterogeneity gradually obscures the classic differences between diabetes types and leads to the emergence of new forms of diabetes. The high heterogeneity of diabetes poses challenges to the accurate classification of diabetes mellitus. It has significance in the prediction, prevention, diagnosis, and treatment of the disease for us to have a deep understanding of the clinical consequences of heterogeneity within and between different diabetes types.
