The functions and mechanisms of kynurenine pathway in cognitive dysfunction

VernacularTitle:犬尿氨酸途径在认知功能障碍中的作用及机制
Author: Lijin JING ¹ ; Jing YANG ; Qizhen ZHOU ; Qi WANG
Author Information

1. 山西医科大学第二医院消化内科，太原　030000
Keywords: Tryptophan; Kynurenine; Cognitive dysfunction; Indoleamine-pyrrole 2, 3-dioxygenase
From: Journal of Chinese Physician 2022;24(1):157-160,f3
CountryChina
Language:Chinese
Abstract: Tryptophan (TRP) is an essential amino-acid and the precursor of many signaling molecules. Under the catalysis of indoleamine 2, 3-dioxygenase, kynurenine pathway can form its metabolites uroquinolinic acid and quinolinic acid, which is the main channel of TRP metabolism.Through different mechanisms in N-methyl-D-aspartate receptor, they participate in nervous modulation, affect cognitive processes and play an important role in many central nervous system diseases development. Kynurenine pathway is different under physiological and pathological conditions. In addition, there are many rate-limiting enzymes in the kynurenine pathway, which can interfere kynurenine pathway. This article reviews the relationship between tryptophan/kynurenine pathway and cognitive dysfunction.