Research progress of the relationship between the effect of laparoscopic sleeve gastrectomy on blood glucose and GLP-1/DPP-4 pathway in obese patients with type 2 diabetes mellitus

VernacularTitle:腹腔镜袖状胃切除术对肥胖2型糖尿病患者血糖的影响及与GLP-1/DPP-4通路关系的研究进展
Author: Yongbin MA ¹ ; Yisireyili MAIMAITI ; Aili AIKEBAIER
Author Information

1. 新疆维吾尔自治区人民医院微创、疝和腹壁外科，乌鲁木齐　830001
Keywords: Gastrectomy; Laparoscopy; Obesity; Diabetes mellitus, type 2; Glucagon-like peptide 1; Dipeptidyl peptidase 4
From: Journal of Chinese Physician 2022;24(1):153-156
CountryChina
Language:Chinese
Abstract: Obesity and type 2 diabetes (T2DM) are all the metabolic diseases with high incidence rate. There is a clear correlation between the them. Weight-loss surgery is the important treatment of surgical method for obesity and T2DM.However, the mechanism of T2DM for weight loss surgery is not yet clear.The secretion level of glucagon like peptide-1 (GLP-1) was affected after weight loss surgery. The secretion of GLP-1 can delay gastric emptying, increase satiety, improve insulin resistance (IR) and promote β insulin release, inhibition of glucagon synthesis and secretion, and improvement of pancreatic function β cell function. All of these changes were conducive to glycemic control. Therefore, this paper aims to summarize and describe the relationship between the effect of laparoscopic sleeve gastrectomy (LSG) on blood glucose and GLP-1/dipeptidyl peptidase-4 (DPP-4) pathway in obese T2DM patients.