Predictive effect of minute ventilation/carbon dioxide production slope on heart failure after acute myocardial infarction
10.3760/cma.j.cn431274-20201221-01713
- VernacularTitle:二氧化碳通气当量斜率对急性心肌梗死后心力衰竭的预测作用
- Author:
Wenjing WU
1
;
Shiyu ZHANG
;
Jingbo SHEN
;
Cui LIU
;
Nan WANG
;
Qing WANG
;
Jingang ZHENG
;
Yihong SUN
Author Information
1. 北京中日友好医院心脏科，北京 100029
- Keywords:
Myocardial infarction;
Heart failure;
Carbon dioxide;
Exercise test
- From:
Journal of Chinese Physician
2022;24(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the independent prognostic value of minute ventilation/carbon dioxide production slope (VE/Vco 2 slope)on heart failure after acute myocardial infarction. Methods:131 patients with acute myocardial infarction (AMI) treated in the cardiology department of China-Japan Friendship Hospital from September 2018 to September 2019 were collected and followed up 3 months after discharge. They were divided into heart failure (HF) group and non-heart failure (NHF) group. All the patients underwent cardiopulmonary exercise test (CPET) before discharge.Results:Three months after discharge, the VE/Vco 2 slope was higher in HF group than in NHF group (36.7±3.8 vs 29.7±4.0, P=0.014). The best VE/Vco 2 slope cutoff for the prediction of heart failure after 3 month was 33.05 with a sensitivity of 81.4% and a specificity of 80.6% [area under curve (AUC) was 0.844, P<0.001]. VE /Vco 2 slope level was an independent predictor of heart failure in patients with acute myocardial infarction after discharge ( OR=1.245, 95% CI: 1.021-1.366, P=0.019). Other independent indicators related to heart failure included N-terminal pro-B type natriuretic peptid (NT-proBNP) level ( OR=1.283, 95% CI: 1.019-1.399, P=0.033). Conclusions:VE/Vco 2 slope yielded strong, independent predictive value for heart failure at 3 month after discharge to AMI patients.
