Clinical study of deep brain stimulation in the treatment of Parkinson′s disease
10.3760/cma.j.cn431274-20200914-01285
- VernacularTitle:脑深部电刺激治疗帕金森病的临床研究
- Author:
Bin ZHOU
1
;
Bo LI
;
Weiping KUANG
;
Bo LIU
;
Hongxing HUANG
;
Xiaosong LI
;
Xiaoye WANG
;
Shucheng ZOU
Author Information
1. 湖南省脑科医院神经外科，长沙 410007
- Keywords:
Electric stimulation therapy;
Deep brain stimulation;
Parkinson disease
- From:
Journal of Chinese Physician
2021;23(12):1782-1785
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of deep brain stimulation (DBS) in the treatment of Parkinson′s disease (PD).Methods:32 PD patients treated in Hunan Brain Hospital from January 2016 to December 2018 were selected for the study. Guided by MRI and supplemented by electrophysiological stimulation to correct the target, PD patients were treated with DBS for the nucleus accumbens. Based on Webster and Unified Parkinsons Disease Rating Scale (UPDRS) scores before and after DBS treatment, the clinical treatment effects were evaluated. And the content of Aβ1-42, interleukin (IL)-1β, IL-6, uric acid (UA), malondialdehyde (MDA), homocysteine (Hcy), S-nitrosylated dynamin-relatedprotein 1 (SNO-Drp1) and Drp1 was measured before and after DBS treatment. The ratio of SNO-Drp1/Drp1 was also measured.Results:The Webster score and UPDRS score of PD patients after DBS treatment were lower than those before DBS treatment ( P<0.05). The Aβ1-42 and Drp1content of PD patients after DBS treatment was higher than that before DBS treatment ( P<0.05), while the content of IL-1β, UA, MDA, Hcy and the ratio of SNO-Drp1/Drp1 were lower than before treatment ( P<0.05). Conclusions:DBS has confirmed a good clinical effect in the treatment of PD patients and significantly improved the quality of life of patients.
