Correlation between serum VEGF level and white matter hyperintensity and cognitive dysfunction in patients with cerebral small vessel disease
10.3760/cma.j.cn371468-20211229-00756
- VernacularTitle:脑小血管病患者血清VEGF水平与脑白质高信号、认知功能障碍的相关性研究
- Author:
Jin WANG
1
;
Jianhua ZHAO
;
Hao LIU
;
Junli LIU
;
Fangli YANG
;
Qiong LI
;
Minghua WANG
;
Panpan ZHAO
;
Fan WANG
;
Qing LI
;
Zhixiu XU
;
Junyan YUE
;
Jian ZHANG
;
Sibei JI
;
Ruiyan CAI
;
Shaomin LI
Author Information
1. 新乡医学院第一附属医院神经内科，河南省神经修复重点实验室，河南省老年性痴呆神经修复国际联合实验室，新乡 453000
- Keywords:
Cerebral small vessel disease;
Vascular endothelial growth factor;
Non-dementia vascular cognitive dysfunction;
White matter hyperintensities;
MRI
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(4):333-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum vascular endothelial growth factor (VEGF) levels and white matter high signal and non-dementia vascular cognitive dysfunction in patients with cerebral small vascular disease (CSVD).Methods:Total 106 patients with CSVD who were admitted to the Department of Neurology of the First Affiliated Hospital of Xinxiang Medical College from April 2019 to December 2020 were enrolled.They were divided into vascular cognitive impairment no dementia group (VCIND group, n=47) and no vascular cognitive impairment group (N-VCI group, n=59)according to mini-mental assessment scale (MMSE), Montreal cognitive assessment (MoCA) scale and activity of daily living scale (ADL). Serum VEGF levels were detected by enzyme-linked immunosorbent assay (ELISA). The baseline data, serum VEGF levels, MoCA score and Fazekas score were compared between the two groups.The correlation between serum VEGF level and white matter high signal and cognitive function was analyzed.SPSS 19.0 software was used for data processing.The statistical methods were t-test, Chi square test, nonparametric test, Logistic regression analysis, Pearson correlation analysis and Spearman correlation analysis. Results:There were significant differences in serum VEGF level((464.18±114.58)pg/mL, (414.17±45.80)pg/mL, F=22.880), MoCA score((13.07±6.48), (20.17±4.06), F=17.920) and Fazekas score (4(3, 5), 3(1, 3), Z=-4.189)between the two groups (all P<0.05). The level of VEGF( β=0.008, OR=1.008, 95% CI=1.001-1.015, P<0.05) was the influencing factor of cognitive function in patients with CSVD .The level of VEGF was negatively correlated with the total score of MoCA, attention and calculation power, and orientation ability ( r=-0.345, -0.373, -0.445, all P<0.05) and it was positively correlated with the total Fazekas score and the Fazekas score of paraventricular and deep white matter ( r=0.392, 0.495, 0.302, all P<0.05). There was a linear trend between the high signal grade of paraventricular and deep white matter and VCIND (both P<0.05). Conclusion:Serum VEGF level is correlated with cognitive function and white matter hyperintensity in patients with CSVD.The increase of VEGF level may be a factor reflecting cognitive dysfunction.In addition, with the increase of white matter hyperintensity level, the risk of VCIND in CSVD is increased.
