Single nucleotide polymorphisms in risk genes of restless legs syndrome: a Meta-analysis

VernacularTitle:不宁腿综合征风险基因单核苷酸多态性的Meta分析
Author: Baoyan WANG ¹ ; Duanyang LI ; Jie WU ; Xiaoxuan WANG ; Rong XUE ; Wei WU
Author Information

1. 天津医科大学总医院空港医院神经内科，天津　300308
Keywords: Restless legs syndrome; Risk genes; Single nucleotide polymorphisms; Case control study; Meta analysis
From: Chinese Journal of Behavioral Medicine and Brain Science 2022;31(2):187-192
CountryChina
Language:Chinese
Abstract: Objective:To investigate the correlation between single nucleic acid polymorphisms (SNPs) of MEIS1, BTBD9, MAP2K5, PTPRD and restless leg syndrome (RLS).Methods:By searching the literatures published before March 1, 2021 at home and abroad, case-control studies on risk genes associated with RLS were collected, and the Review Manager 5.3 and Stata 15.1 softwares were used for statistical analysis.Results:A total of 8 studies were included, with a total of 7 824 cases and 14 645 controls.Meta analysis results showed that the SNPs locus of the risk gene associated with RLS was MEIS1 rs2300478( OR=1.68, 95% CI: 1.59-1.78), BTBD9 rs9296249( OR=1.62, 95% CI: 1.47-1.77), BTBD9 rs9357271( OR=1.49, 95% CI: 1.44-1.55), MAP2K5 rs12593813( OR=1.44, 95% CI: 1.36-1.53), MAP2K5 rs11635424( OR=1.47, 95% CI: 1.34-1.60)and PTPRD rs1975197( OR=1.34, 95% CI: 1.21-1.49). Conclusion:MEIS1 rs2300478, BTBD9 rs9296249, BTBD9 rs9357271, MAP2K5 rs12593813, MAP2K5 rs11635424 and PTPRD rs1975197 are the risk loci of RLS.