Correlation between serum VEGF level and clinical symptoms in patients with first-episode drug-naive schizophrenia of different genders
10.3760/cma.j.cn371468-20211106-00632
- VernacularTitle:不同性别首发未用药精神分裂症患者血清VEGF水平与临床症状的相关性
- Author:
Peng CHEN
1
;
Huimin ZHAO
;
Xuyuan YIN
;
Zhenhua ZHU
;
Qi QI
;
Caixia JIANG
;
Ying YUAN
;
Linghua KONG
;
Zhenyong GAO
;
Ping YANG
;
Qiufang JIA
;
Li HUI
Author Information
1. 苏州市广济医院精神康复科，苏州 215137
- Keywords:
Schizophrenia;
First-episode drug-naive;
Vascular endothelial growth factor;
Gender;
Negative symptoms;
Cognition
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(2):136-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the level of serum vascular endothelial growth factor (VEGF) and its correlation with clinical symptoms in patients with first-episode drug-naive schizophrenia patients of different genders.Methods:From January 2016 to October 2019, a total of 81 first-episode drug-naive schizophrenia patients(patient group, 41 male, 40 female) and 64 healthy controls (control group, 40 male, 24 female) were included in this study.The serum level of VEGF was detected with flow cytometric bear array (CBA). Positive and negative symptom scale (PANSS) was used to evaluate the relevant clinical symptoms of patients.SPSS 22.0 software was used for statistical analysis.Independent sample t-test and nonparametric test were used for comparison between groups.The relationship between VEGF and clinical variables was analyzed by Pearson correlation analysis and Spearman correlation analysis. Results:The level of serum VEGF in the patient group was significantly lower than that in the control group(148.08(75.89, 208.61)pg/mL, 179.94(99.14, 318.41)pg/mL, Z=-2.20, P=0.028). The total PANSS score((82.71±17.30), (73.45±16.36), t=2.473, P=0.016)and cognitive score((7.88±3.36), (6.23±2.81), t=2.402, P=0.019) in male patients were higher than those in female patients.There was a negative correlation between VEGF level and PANSS negative symptom score in the patient group( r=-0.228, P=0.041), as well as significant negtive correlation between VEGF level and cognitive score in male patients( r=-0.425, P=0.007). Conclusion:The level of serum VEGF is reduced in first-episode patients with schizophrenia, which influences their negative symptom. Moreover, the decline in serum VEGF level is implicated in cognitive impairments in male patients with first-episode schizophrenia.
