The difference of gray matter volume and its correlation with clinical characteristics in patients with anxious depression
10.3760/cma.j.cn371468-20210930-00567
- VernacularTitle:焦虑性抑郁症患者脑灰质体积变化及其与临床特征的相关性
- Author:
Juan QIAO
1
;
Rui YAN
;
Yu CHEN
;
Jiabo SHI
;
Xinyi WANG
;
Zhijian YAO
;
Qing LU
Author Information
1. 南京医科大学附属脑科医院精神科，南京 210029
- Keywords:
Anxious depression;
Gray matter volume;
Structural magnetic resonance imaging;
Prefrontal lobe;
Correlation analysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(1):25-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the difference of gray matter volume between anxious depression(AD)and non anxious depression(NAD) patients, and its correlation with clinical characteristics.Methods:One hundred and fifty patients with depression were included from September 2014 to October 2018, meanwhile 62 healthy controls with matching demographic characteristic were recruited. The severity of the patients was assessed by Hamilton depression scale-17(HAMD-17). Patients were divided into anxious depression group(AD group, n=80)and non-anxious depression group (NAD group, n=70) according to whether anxiety/somatization factor scored 7. All subjects were scanned with 3.0 T underwent structural MRI scan. The structural magnetic resonance data were preprocessed by voxel-based morphometry (VBM). The rest toolkit was used to calculate the difference of gray matter volume among the three groups. By SPSS 19.0, post-hoc t test was used for pairwise comparison and Pearson correlation analysis was performed between gray matter volume and clinical factors in patients with anxious depression. Results:Compared to the NAD group, the gray matter volume of the right middle frontal gyrus(MNI: x=28.5, y=21.0, z=48.0, t=-4.83, Bonferroni multiple comparison adjustment, P<0.05/3) and left dorsolateral superior frontal gyrus(MNI: x=-18.0, y=27.0, z=43.5, t=-6.08, Bonferroni multiple comparison correction, P<0.05/3)were significantly decreased in AD group. Correlation analysis found that the gray matter volume of the right middle frontal gyrus in patients with anxious depression was negatively correlated with the insight of anxiety/somatization factor score ( r=-0.36, P=0.001). Conclusion:The volume of prefrontal lobe in patients with anxiety depression is lower than that in patients with non anxiety depression, which may be related to the serious clinical symptoms in patients with anxiety depression.The decrease of right middle frontal gyrus volume can be used as a potential biological marker for the severity of impaired insight.
