Functional magnetic resonance study on static and dynamic amplitude of low frequency fluctuation in male smoking addicts
10.3760/cma.j.cn371468-20210624-00347
- VernacularTitle:吸烟成瘾男性脑静态及动态低频振幅的功能磁共振研究
- Author:
Xinyu GAO
1
;
Yong ZHANG
;
Mengmeng WEN
;
Mengzhe ZHANG
;
Zhengui YANG
;
Huiyu HUANG
;
Weijian WANG
;
Jingliang CHENG
Author Information
1. 郑州大学第一附属医院磁共振科 450002
- Keywords:
Smoking;
Magnetic resonance imaging;
Amplitude of low-frequency fluctuation;
Male;
Substance addiction
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2021;30(12):1077-1081
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differences of static and dynamic spontaneous brain activity between male smoking addicts and healthy controls, and analyze the mechanism of smoking addiction.Methods:Based on static amplitude of low-frequency fluctuation (sALFF) and dynamic amplitude of low frequency fluctuation (dALFF), the differences of static and dynamic spontaneous brain activity were compared between male smoking addicts ( n=63) and healthy controls ( n=30) by independent sample t-test. Pearson correlation analysis was used to investigate the relationships between the altered dALFF values and score of Fagerstr?m test for nicotine dependence(FTND) and pack-years of smoking addicted males. Results:Compared with healthy controls, the values of sALFF in the left superior/middle/inferior orbitofrontal gyrus ( t=5.17, clusters≥108) were increased and the variation of dALFF in the right superior temporal/middle gyrus, left orbitofrontal region, left orbital superior/middle/inferior frontal gyrus, right orbitofrontal gyrus/middle/inferior frontal gyrus and right putamen ( t=4.90, 4.37, 4.91, 4.62, 4.59, clusters≥96) were also increased in the smoking addicted group. It was noteworthy that the dALFF values of the right superior temporal/middle gyrus( r=0.252, P=0.047), left orbital region superior frontal gyrus( r=0.281, P=0.026) and right putamen( r=0.313, P=0.012) were positively correlated with pack-years of male smoking addicts. Conclusion:Male smoking addicts may have abnormal static and dynamics spontaneous neural activity in prefrontal cortex (including orbital frontal lobe), putamen and superior temporal/middle gyrus, which are correlated with pack-years.
