Research progress in mechanism of necroptosis in acute pancreatitis
10.3760/cma.j.cn121430-20211125-01783
- VernacularTitle:坏死性凋亡在急性胰腺炎作用机制中的研究进展
- Author:
Yujie LIN
1
;
Jihong XIAO
;
Xin LIU
;
Xiangli MA
;
Chaoze JIAO
;
Peiwu LI
Author Information
1. 兰州大学第二医院急救中心，甘肃兰州 730030
- Keywords:
Acute pancreatitis;
Regulated cell death;
Necroptosis;
Autophagy;
Ferroptosis
- From:
Chinese Critical Care Medicine
2022;34(3):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis (AP) is a common and potentially threatening disease of the pancreas, and some patients eventually develop to severe acute pancreatitis (SAP). Symptomatic support therapies such as rehydration therapy and anti-infection are still the main treatments. Lacking specific therapies is the main reason for the high mortality of AP patients, especially those with SAP. Premature trypsinogen activation is the most important pathologic cellular event in the pathogenesis of AP. The release of trypsin can cause self-digestion inside and outside of acinar cells, especially the release of cathepsin B can also cause a caspase-unrelated regulatory cell death (RCD) known as necroptosis, which is closely related to the development and prognosis of AP. Therefore, it is necessary to further study the mechanism of necroptosis in the occurrence and development of AP. This article reviews the mechanism of necroptosis and the research progress related to AP, in an attempt to provide a new understanding of the pathogenesis and treatment of AP, and promote the better target drug development.
