Research progress of sepsis associated encephalopathy influenced by gut microbiota via efferocytosis

VernacularTitle:肠道菌群通过胞葬影响脓毒症相关性脑病的研究进展
Author: Hongsen LIAO ¹ ; Haojia LI ; Yanna SI ; Hongguang BAO
Author Information

1. 南京医科大学附属南京医院（南京市第一医院）麻醉科，江苏南京　210006
Keywords: Sepsis associated encephalopathy; Neuroinflammation; Gut microbiota; Efferocytosis
From: Chinese Critical Care Medicine 2022;34(2):194-197
CountryChina
Language:Chinese
Abstract: Sepsis associated encephalopathy (SAE) is a severe disease secondary to sepsis, which is associated with increased mortality and causes long-term cognitive deficits in survivors. Recently, an increasing body of evidence has shown that gut microbiota is closely related to the central nervous system, and could influence brain function via microbiota-gut-brain axis. Therefore, in the occurrence and development of SAE, cholinergic anti-inflammatory pathway is one of the mechanisms by which gut microbiota could improve cognitive function. Efferocytosis, a process of eliminating apoptotic cells in the body, has anti-inflammatory effects and provides organ protection in sepsis. On the other hand, it could be enhanced by some metabolites of gut microbiota, making it another potential mechanism for gut microbiota regulating SAE. This review summarizes the mutual regulation of gut microbiota, efferocytosis and SAE, to explore potential mechanisms and therapeutic targets of SAE.