Advance in sepsis-related coagulation disorders and immunity response

VernacularTitle:脓毒症相关凝血功能紊乱与免疫反应相关机制的研究进展
Author: Jin LI ¹ ; Yan WANG ; Yawei ZENG ; Chao WANG ; Wenjie QI
Author Information

1. 首都医科大学附属北京友谊医院感染内科，北京　100050
Keywords: Sepsis; Coagulation function; Disseminated intravascular coagulation; Immunity
From: Chinese Critical Care Medicine 2021;33(12):1519-1523
CountryChina
Language:Chinese
Abstract: Coagulation disorder or disseminated intravascular coagulation (DIC) is a clinicopathological syndrome, in which the imbalance between coagulation and fibrinolysis is the main pathogenesis, and systemic microthrombosis and systemic bleeding tendency are the main clinical manifestations. The clinical outcome is often the induction of systemic multiple organ dysfunction. As a common complication of sepsis, DIC significantly increases the mortality of septic patients. The coagulation disorder in sepsis is closely related to the inflammatory response of the body. Studying the mechanism of sepsis-related coagulation disorder will provide new possibilities for its early diagnosis and prognosis evaluation. This article reviews the latest research progress on the molecular mechanism of sepsis-related coagulation disorders in immunity and inflammation, in order to provide new possibilities for potential therapeutic targets.