Potential regulatory role of long non-coding RNA-microRNA-mRNA axis in sepsis

VernacularTitle:长链非编码RNA-微小RNA-mRNA轴在脓毒症中的调控作用研究进展
Author: Qiqi TANG ¹ ; Guanghui XIU ; Yingxuan GUO ; Jie SUN ; Bin LING
Author Information

1. 云南大学附属医院（云南省第二人民医院）重症医学科，昆明　650021
Keywords: Sepsis; Multiple organ dysfunction; Long non-coding RNA; MicroRNA; Messenger RNA
From: Chinese Critical Care Medicine 2021;33(12):1514-1518
CountryChina
Language:Chinese
Abstract: Sepsis is a life-threatening multiple organ dysfunction disease with high mortality and has become leading causes of death affecting intensive care unit (ICU) patients. Both long non-coding RNA (lncRNA) and microRNA (miRNA) are involved in the pathophysiological process of sepsis and can regulate the inflammatory response, both of which could be used as important diagnostic indicators and therapeutic targets of sepsis. The interaction among lncRNA, miRNA and messenger RNA (mRNA) plays an important role in sepsis and multiple organ dysfunction. This paper reviewed the regulatory relationship of lncRNA, miRNA and mRNA, as well as the regulatory role of lncRNA-miRNA-mRNA axis in inflammatory immune response and multiple organ dysfunction syndrome in sepsis, to provide new targets and strategies for the treatment of sepsis and organ dysfunction.