Research progress of methylene blue in the treatment of sepsis and septic shock

VernacularTitle:亚甲蓝治疗脓毒症及脓毒性休克的研究进展
Author: Jinfang XUE ¹ ; Xiran LOU ; Guobing CHEN
Author Information

1. 昆明理工大学医学院，云南昆明　650500
Keywords: Sepsis; Septic shock; Methylene blue; Nitric oxide
From: Chinese Critical Care Medicine 2021;33(11):1384-1387
CountryChina
Language:Chinese
Abstract: Sepsis and septic shock have high morbidity and mortality. The key point is that huge amount of nitric oxide (NO) is releasing into circulation, inducing marked dilation of blood vessels, and continuously decreased of blood pressure. The central link is inflammation and oxidative stress. Methylene blue can effectively inhibit NO, remove excessive NO and block the signal transduction pathway named inducible nitric oxide synthase-NO-soluble guanylate cyclase-cyclic guanosine monophosphate (iNOS-NO-sGC-cGMP). Meanwhile, it also play a role in inhibiting oxidative stress and inflammation. This paper reviews the mechanism of methylene blue in the treatment of sepsis and septic shock, as well as its treatment time window, optimal dose, administration mode and potential adverse reactions, to provide new ideas for clinical treatment.