Association of MCP-1 polymorphism with cardiovascular disease risk factors in Korean elderly.
10.4163/jnh.2013.46.6.511
- Author:
Hee Jung PARK
1
Author Information
1. Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea. 5919park@gmail.com
- Publication Type:Original Article
- Keywords:
MCP-1;
MCP-1 polymorphism;
dietary factors;
Korean elders
- MeSH:
Aged*;
Cardiovascular Diseases*;
Chemokine CCL2;
Cholesterol;
Genotype;
Humans;
Hypercholesterolemia;
Meat;
Polymorphism, Genetic;
Regulatory Sequences, Nucleic Acid;
Risk Factors*;
Tumor Necrosis Factor-alpha
- From:Journal of Nutrition and Health
2013;46(6):511-520
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in cardiovascular disease (CVD). Genetic polymorphism in the regulatory regions of MCP-1 could affect MCP-1 expression. The purpose of the study was to explore the possible association of MCP-1 -2518 A/G genetic polymorphism and CVD risk factors in the elderly Korean population. Dietary, anthropometric, and biochemical factors were assessed in 168 subjects. The frequency of A/A, G/A, and G/G genotypes was 14.2%, 45.8%, and 40.0%, respectively. The blood level of MCP-1 was significantly higher in subjects with A/A genotype. The MCP-1 level was significantly higher in A/A genotype with hypercholesterolemia than in other genotypes. Meat intake and percent energy from lipids were significantly positively correlated with the MCP-1 level, especially, stronger in A/A genotype. In the stepwise discriminant analysis, TNF-alpha level, meat intake, HDL-C were associated with MCP-1 in all subjects (model R2 = 24%). TNF-alpha level, sugar intake, cholesterol intake, and meat intake affected MCP-1 in A/A genotype (model R2 = 82%), but not in G/A or G/G. In conclusion, subjects possessing A/A genotype exhibited higher levels of MCP-1 than other genotypes in Korean elders. Further, meat, sugar, and cholesterol intakes affected the MCP-1 level. Therefore, the decrement of meat, sugar, and cholesterol intakes helps to normalize the MCP-1 level and can decrease CVD risk in A/A genotype.
