Effect of oxidative stress response in acute respiratory distress syndrome caused by influenza
10.3760/cma.j.cn121430-20210609-00854
- VernacularTitle:氧化应激反应在流感病毒相关ARDS中作用的研究进展
- Author:
Yongxin ZHENG
1
;
Yongbo HUANG
;
Xiaoqing LIU
;
Yimin LI
Author Information
1. 呼吸疾病国家重点实验室，广州呼吸健康研究院，广州医科大学附属第一医院呼吸与危重症医学科，广东广州 510120
- Keywords:
Influenza virus;
Acute respiratory distress syndrome;
Reactive oxygen species;
Oxidative stress;
Antioxidants
- From:
Chinese Critical Care Medicine
2021;33(10):1272-1276
- CountryChina
- Language:Chinese
-
Abstract:
Influenza virus is one of the common pathogens causing acute respiratory infectious diseases, and is easy to cause acute respiratory distress syndrome (ARDS) after infecting human body, which is an important cause of death of influenza patients. Influenza-induced ARDS results from a combination of overwhelming inflammation and immune response, causing tissue damage and apoptosis. Furthermore, virus-mediated oxidative stress is another important mechanism. Viral infection can produce excessive reactive oxygen species, which damage the epithelial-endothelial barrier with pulmonary edema. In this content, numerous studies have highlighted the importance of antioxidants as a new therapy aimed at blocking both viral replication and virus-induced inflammation. Therefore, this paper summarizes the epidemiology and mechanisms of influenza-induced ARDS, the role of oxidative stress in the occurrence and development of influenza-related ARDS and the role of antioxidants in anti influenza virus infection, in order to provide reference for effective treatment of influenza patients, reducing mortality, developing new anti influenza drugs and preventing and controlling influenza epidemic.
