Low protein diet combined with α-keto acid improves calcium and phosphorus metabolic disorders and nutritional status in hemodialysis patients: a meta-analysis
10.3760/cma.j.cn115822-20210923-00190
- VernacularTitle:低蛋白饮食联合α酮酸改善血液透析患者钙磷代谢紊乱及营养状况的Meta分析
- Author:
Xueqin LIU
1
;
Xiaohui LIU
;
Ying ZHANG
;
Wei WEI
;
Yaqi WU
;
Xiao JIANG
Author Information
1. 河南中医药大学护理学院，郑州450046
- Keywords:
Low protein diet;
Alpha-keto acid;
Hemodialysis;
Calcium and phosphorus metabolism;
Nutrition;
Meta-analysis
- From:
Chinese Journal of Clinical Nutrition
2022;30(1):37-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the effects of low protein diet combined with α-keto acid on calcium and phosphorus metabolism and nutritional status in patients undergoing hemodialysis.Method:Randomized controlled Trials were searched in Cochrane Library, Web of Science, PubMed, Embase, CBM, CNKI, Wanfang and VIP databases from the establishment of respective database until July 2021, and meta-analysis is conducted using RevMan 5.4.Results:A total of 8 studies including 556 patients were selected. Meta-analysis showed that after receiving low protein diet combined with α-keto acid, patients demonstrated significantly reduced blood phosphorus [MD = -0.17, 95% CI (-0.25, -0.7), P < 0.01], calcium- phosphorus product [MD = -6.17, 95% CI (-6.67, -5.58), P < 0.01] and parathyroid hormone levels [MD = -35.36, 95% CI (-40.89, -29.83), P < 0.01]. There was no significant difference in serum calcium [MD = 0.03, 95% CI (-0.00, 0.07), P = 0.08] and serum albumin [MD = 0.41, 95% CI (-0.12, 0.95), P = 0.13]. Conclusion:Low protein diet combined with α-keto acid can reduce the levels of serum phosphorus, calcium-phosphorus product and parathyroid hormone in hemodialysis patients while the effects on serum calcium and serum albumin are undetermined and need further verification.
