Effect of oat beta-glucans on blood levels of lipids, glucose and inflammatory factors in participants with hyperlipemia/hyperglycemia: an exploratory, prospective, single-center, randomized, double-blind, placebo-controlled study
10.3760/cma.j.cn115822-20210104-00001
- VernacularTitle:燕麦β葡聚糖对高脂血症/高血糖患者血脂、血糖和炎症因子影响的探索性、前瞻性、单中心、随机、双盲、安慰剂对照研究
- Author:
Xiaodong NIE
1
;
Kang YU
;
Zhuo LI
;
Fang WANG
;
Yuanyuan BAO
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院临床营养科 100730
- Keywords:
Oat beta-glucans;
Hyperlipemia;
Hyperglycemia;
Inflammatory factors
- From:
Chinese Journal of Clinical Nutrition
2021;29(5):257-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of oat beta-glucans on blood levels of lipids, glucose, and inflammatory factors in patients with hyperlipemia/hyperglycemia.Methods:A total of 120 patients with hyperlipemia/hyperglycemia were randomized into intervention ( n = 60) and control groups ( n = 60). In addition to the routine nutritional consultation, two groups received oral oat beta-glucan at 3 g/d (intervention) or lotus root powder at 3 g/d (control), respectively. Blood levels of lipids, glucose, insulin and inflammatory factors, body composition and bowel movement were compared between the two groups after 12 weeks of study intervention. The treatment effect was represented by intention-to-treat analysis. Results:A total of 109 participants completed the study. The total cholesterol [(5.18±0.69) mmol/L vs (5.25±0.88) mmol/L, P=0.024] and fasting plasma glucose [(5.50±0.82) mmol/L vs (5.98±1.33) mmol/L, P=0.002] in the intervention group were significantly decreased compared with the control group. Conclusion:Oral oat beta-glucans could decrease the total cholesterol and fasting plasma glucose in participants with mild hyperlipemia/hyperglycemia.
