Efficacy of combined fluoxetine and aniracetam tablets in the treatment of senile depression and its effects on serum total bile acid and norepinephrine levels
10.3760/cma.issn1008-6706.2022.02.003
- VernacularTitle:氟西汀联合茴拉西坦治疗老年抑郁症疗效观察及对患者血清总胆汁酸、去甲肾上腺素水平的影响
- Author:
Ying LIU
1
;
Jicheng YUAN
;
Guoping WANG
Author Information
1. 菏泽医学专科学校护理学系，菏泽 274000
- Keywords:
Fluoxetine;
Aniracetam tablets;
Aged;
Depression;
Efficacy;
Adverse reactions;
Hamilton depression scale;
Hamilton anxiety scale
- From:
Chinese Journal of Primary Medicine and Pharmacy
2022;29(2):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of combined fluoxetine and aniracetam tablets in the treatment of senile depression and its effects on serum total bile acid (TBA) and norepinephrine (NE) levels.Methods:A total of 100 older adult patients with depression who received treatment in Heze Medical College from January 2019 to December 2019 were included in this study. They were randomly assigned to receive either fluoxetine tablets alone (control group, n = 50) or fluoxetine and aniracetam tablets (study group, n = 50). All patients received two months of treatment. Clinical efficacy, scores of the Hamilton Rating Scale for Anxiety (HAMA) and the Hamilton Rating Scale for Depression (HAMD), adverse reactions, and serum TBA and NE levels were compared between the two groups. Results:Total response rate was significantly higher in the study group than in the control group [96.0% (48/50) vs. 84.0% (42/50), χ2 = 4.00, P = 0.045]. HAMD and HAMA scores post-treatment in the study group were (5.85 ± 1.81) points and (4.81 ± 1.57) points, respectively, which were significantly lower than those in the control group [(11.65 ± 2.65) points, (10.85 ± 2.84) points, t = 10.84, P < 0.001; t = 11.16, P < 0.001). Serum NE level was significantly higher in the study group than in the control group [(138.68 ± 16.35) ng/L vs. (127.17 ± 14.34) ng/L, t = 3.17, P = 0.002]. There were no significant differences in serum TBA level [(5.85 ± 0.63) μmol/L vs. (5.91 ± 0.65) μmol/L] and the incidence of adverse reactions (8.00% vs. 6.00%) between the study and control groups ( t = 0.39, P = 0.692; χ2 = 0.15, P = 0.695). Conclusion:The combined therapy of fluoxetine and aniracetam tablets for the treatment of senile depression is safe and highly effective, does not affect metabolic function and thereby deserves clinical application.
