Advances of the effects of maternal iodine nutrition level on neurodevelopment of offspring during pregnancy
10.3760/cma.j.cn231583-20210922-00311
- VernacularTitle:妊娠期母体碘营养水平对子代神经发育影响的研究进展
- Author:
Sihan WANG
1
;
Lijun FAN
;
Dianjun SUN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心 国家卫生健康委病因流行病学重点实验室，哈尔滨 150081
- Keywords:
Pregnancy;
Iodine nutrition;
Thyroid;
Neurodevelopment
- From:
Chinese Journal of Endemiology
2022;41(4):335-340
- CountryChina
- Language:Chinese
-
Abstract:
With the effective implementation of universal salt iodization measures to prevent iodine deficiency disorders, severe iodine deficiency in pregnant women has been rare. However, due to the difficulty in changing the state of iodine deficiency in natural environment and insufficient iodine intake in diet to meet the iodine nutritional needs during pregnancy, mild or moderate iodine deficiency in pregnancy still occurs frequently, and may have adverse effects on the development of nervous system of their offspring. At the same time, the effect of excessive iodine intake of pregnant women on the development of nervous system of their offspring can not be ignored. In addition, if the ability of thyroid regulation in pregnant women is out of balance that leads to thyroid dysfunction and even hormone secretion disorder, which can not meet the needs of fetal growth and development, it may also affect the nervous system function of their offspring. This paper summarizes the human population studies in recent years: the effects of maternal mild to moderate iodine deficiency, iodine excess, abnormal thyroid function and thyroid hormone treatment on neuro development of offspring, and the mechanism of corresponding animal iodine related exposure experiments, in order to provide scientific basis for "precise prevention and treatment" of iodine deficiency disorders in the future.
