Detection of serum Col2-3/4 C-terminal cleavage product of type Ⅱ collagen and pyridinoline among brucellosis patients at early period in Qinghai
10.3760/cma.j.cn231583-20201104-00282
- VernacularTitle:青海早期布鲁氏菌病患者血清Ⅱ型胶原羧基末端3/4片段和吡啶啉检测结果分析
- Author:
Zhijun ZHAO
1
;
Qiang LI
;
Xin ZHOU
;
Lansheng HU
;
Cuiling LA
;
Jiquan LI
;
Di FAN
;
Jianling WANG
;
Hongmei XUE
;
Yuanbo ZHAO
;
Zhongzhi ZHAO
;
Liqing XU
Author Information
1. 青海省地方病预防控制所布病预防控制科，西宁 810021
- Keywords:
Brucellosis;
Serum;
Pyridinoline
- From:
Chinese Journal of Endemiology
2021;40(12):976-978
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect serum Col2-3/4 C-terminal cleavage product of type Ⅱ collagen (C2C) and pyridinoline (PYD) among brucellosis patients at early period, and to provide a better understanding of the changes of bone and joint collagen metabolism in the early stage of brucellosis.Methods:From 2013 to 2016, 61 cases of brucellosis patients at early period (within 6 months) from brucellosisout patient of Qinghai Institute for Endemic Disease Prevention and Control were selected as case group, and 67 cases of healthy volunteers were selected as control group. Serum C2C and PYD levels in all samples were measured simultaneously with enzyme linked immunosorbent assay (ELISA).Results:The median serum C2C of patients with early brucellosis was 83.45 ng/ml and that of the control group was 73.35 ng/ml. There was significant difference in serum C2C between the case group and the control group ( Z = 5.027, P < 0.05). The median serum PYD of patients with early brucellosis was 278.45 nmol/L and that of the control group was 212.75 nmol/L. There was significant difference in serum PYD between the case group and the control group ( Z = 6.967, P < 0.05). Conclusion:Serum C2C and PYD levels of brucellosis patients at early period are increased.
