The differential diagnosis of pancreatic acinar cell carcinoma and pancreatic ductal adenocarcinoma based on multidetector computed tomography features
10.3760/cma.j.cn115667-20211016-00185
- VernacularTitle:基于多排螺旋CT影像特征的胰腺腺泡细胞癌与胰腺导管腺癌的鉴别诊断
- Author:
Qi LI
1
;
Haiyan ZHAO
;
Na LI
;
Yinghao MENG
;
Xiaochen FENG
;
Tiegong WANG
;
Kai CAO
;
Chao MA
;
Yun BIAN
;
Chengwei SHAO
Author Information
1. 海军军医大学第一附属医院放射诊断科，上海 200433
- Keywords:
Pancreatic neoplasms;
Pancreatic acinar cell carcinoma;
Pancreatic ductal adenocarcinoma;
Diagnosis, differential;
Tomography, X-ray computed
- From:
Chinese Journal of Pancreatology
2021;21(6):461-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differential diagnosis of pancreatic acinar cell carcinoma (PACC) and pancreatic ductal adenocarcinoma (PDAC) based on multidetector computed tomography (MDCT) features.Methods:The clinical, pathological and MDCT imaging data of 26 patients with pathologically confirmed PACC and 145 patients with pathologically confirmed PDAC who underwent MDCT from November 2013 to April 2021 were retrospectively studied. The differences of MDCT features including tumor location, tumor size, common pancreatic duct and bile duct dilatation, pancreatitis, lymph node metastasis, cyst, pancreatic parenchyma atrophy, duodenal involvement, bile ductal and vascular involvement between the two groups were compared. Univariate analysis and multivariate analysis by logistic regression models were performed to identify the independent predictive factors for PACC.Results:The tumor size, bile duct dilatation, lymph node metastasis, pancreatic parenchyma atrophy and vascular involvement were significantly different between PACC group and PDAC group (all P value<0.05). Multivariate analysis revealed that the tumor size ( OR=1.07, 95% CI 1.028-1.15, P=0.001), lymph node metastasis ( OR=0.23, 95% CI 0.065-0.800, P=0.02), pancreatic parenchyma atrophy ( OR=0.15, 95% CI 0.048-0.490, P=0.002) were closely associated with PACC. Conclusions:The tumor size, bile duct dilatation, lymph node metastasis, pancreatic parenchyma atrophy and vascular involvement evaluated by MDCT had a certain value in differentiating PACC from PDAC, and the tumor size, lymph node metastasis and pancreatic parenchyma atrophy were independent predictors for the diagnosis of PACC.
