Anti-inflammatory and analgesic properties of Moroccan medicinal plants:Phytochemistry,in vitro and in vivo investigations,mechanism insights,clinical evidences and perspectives
- Author:
Bouyahya ABDELHAKIM
1
;
Guaouguaou FATIMA-EZZAHRAE
;
Omari El NASREDDINE
;
Menyiy El NAOUAL
;
Balahbib ABDELAALI
;
El-Shazly MOHAMED
;
Bakri YOUSSEF
Author Information
1. Laboratory of Human Pathologies Biology,Department of Biology,Faculty of Sciences,and Genomic Center of Human Pathologies,Faculty of Medicine and Pharmacy,Mohammed V University in Rabat,4014,Morocco
- Keywords:
Inflammation;
Medicinal plants;
Bioactive compounds;
Anti-inflammatory;
Analgesic
- From:
Journal of Pharmaceutical Analysis
2022;12(1):35-57
- CountryChina
- Language:Chinese
-
Abstract:
Moroccan medicinal plants exhibit several pharmacological properties such as antimicrobial,anticancer,antidiabetic,analgesic,and anti-inflammatory effects,which are related to the presence of numerous bioactive compounds,including phenolic acids,flavonoids,and terpenoids.In the present review,we systematically evaluate previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal plants.The in vitro investigations revealed that Moroccan medicinal plants inhibit several enzymes related to inflammatory processes,whereas in vivo studies noted significant anti-inflammatory and analgesic effects as demonstrated using different experimental models.Various bioactive compounds exhibiting in vitro and in vivo anti-inflammatory and analgesic effects,with diverse mechanisms of action,have been identified.Some plants and their bioactive compounds reveal specific secondary metabolites that possess important anti-inflammatory effects in clinical investigations.Our review proposes the potential applications of Moroccan medicinal plants as sources of anti-inflammatory and analgesic agents.
