Capillary electrophoresis methods for impurity profiling of drugs:A review of the past decade
- Author:
Shah MANSI
1
;
Patel NRUPESH
;
Tripathi NAGJA
;
K.Vyas VIVEK
Author Information
1. Department of Pharmaceutical Analysis,Institute of Pharmacy,Nirma University,Ahmedabad,382 481,Gujarat,India
- Keywords:
Capillary electrophoresis;
Impurities;
Impurity profiling;
Drugs
- From:
Journal of Pharmaceutical Analysis
2022;12(1):15-28
- CountryChina
- Language:Chinese
-
Abstract:
Capillary electrophoresis(CE)is widely used for the impurity profiling of drugs that contain stereo-chemical centers in their structures,analysis of biomolecules,and characterization of bio-pharmaceuticals.Currently,CE is the method of choice for the analysis of foodstuffs and the determination of adulterants.This article discusses the general theory and instrumentation of CE as well as the classification of various CE techniques.It also presents an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade.The review briefly presents a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples.This review will help scientists,fellow researchers,and students to understand the applications of CE techniques in the impurity profiling of drugs.
