Effects of milnacipran and paroxetine on anxiety state and headache severity of patients with generalized anxiety disorder
10.3760/cma.j.cn115455-20210111-00058
- VernacularTitle:米那普仑与帕罗西汀治疗广泛性焦虑障碍对患者焦虑状态和头痛程度的影响
- Author:
Yang QIN
1
;
Siyuan CHEN
;
Binglun LIU
Author Information
1. 枣庄市精神卫生中心医学心理科，枣庄 277103
- Keywords:
Anxiety;
Headache;
Milnacipran;
Paroxetine;
Quality of life
- From:
Chinese Journal of Postgraduates of Medicine
2022;45(6):510-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of milnacipran and paroxetine on anxiety state and headache severity of patients with generalized anxiety disorder (GAD).Methods:Ninety-six patients with GAD treated in Zaozhuang Mental Health Center from January 2019 to September 2020 were selected and randomly divided into the paroxetine group (treatment with oral paroxetine) and the milnacipran group (treatment with oral milnacipran), each group with 48 cases. A course of treatment consists of 4 weeks. After 3 months of regular medication, the clinical efficacy, Hamilton Anxiety Scale (HAMA) scores, visual analogue scale (VAS) scores, migraine-specific quality of life questionnaire (MSQ V2.1) scores, and Headache Impact Test-6 (HIT-6) scores were compared between the two groups. Adverse reactions during the treatment were recorded in both groups.Results:The total effective rate in the milnacipran group at 4 weeks and 3 months after treatment were significantly higher than those in the paroxetine group: 47.92%(23/48) vs. 22.92%(11/48), χ2 = 6.56, P<0.05; 75.00%(36/48) vs. 51.47%(26/48), χ2 = 4.55, P<0.05. After treatment for 4 weeks and 3 months, the HAMA scores, VAS scores, MSQ V2.1 scores and HIT-6 scores in the milnacipran group were significantly lower than those in the paroxetine group ( P<0.05). The difference of incidence of adverse reactions in the two groups had no statistical significance ( P>0.05). Conclusions:For patients with GAD, the treatment effect of milnacipran is more significant than paroxetine, which can not only reduce patients′ anxiety state and headache degree, but also improve their specific quality of life, with high safety.
