Application value of non-invasive prenatal genetic testing technology in twin pregnancy
10.3760/cma.j.cn115455-20211118-01336
- VernacularTitle:无创产前基因检测技术在双胎妊娠中的应用价值
- Author:
Ming SHI
1
;
Yuan ZHANG
;
Jing ZHANG
;
Shu WANG
;
Chunming CUI
;
Xiaoxue LIU
;
Wenxiu ZHU
;
Wei WANG
;
Xiaoguang SHAO
Author Information
1. 大连市妇女儿童医疗中心（集团）体育新城院区检验科，大连 116037
- Keywords:
Pregnancy, multiple;
Prenatal diagnosis;
Non-invasive prenatal testing;
DNA
- From:
Chinese Journal of Postgraduates of Medicine
2022;45(6):493-497
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application value of non-invasive prenatal testing (NIPT) technology in twin pregnancy.Methods:A total of 339 twin pregnant women who underwent NIPT at Dalian Municipal Women and Children′s Medical Center(Group), Dalian Jinpu New District Maternity and Child Health Hospital, and Dalian Lvshunkou District People′s Hospital from July 1, 2019 to June 30, 2021 were continuously retrospectively included. The clinical characteristics and test results of pregnant women with high-risk and low-risk were analyzed.Results:Among 339 pregnant women, 336 were successfully tested, with a success rate of 99.12%(336/339); 6 pregnant women were at high risk of NIPT, with a positive screening rate of 1.77%(6/339), including 1 case of high risk of trisomy 13, 2 cases of high risk of trisomy 18, and 3 cases of high risk of Trisomy 21; the results of amniocentesis for 2 high-risk pregnant women were not abnormal.Conclusions:NIPT technology is non-invasive, safe and efficient, and is suitable for large-scale prenatal screening. However, the detection accuracy of pregnant women with twin pregnancy needs to be improved.
