Correlation between lesion volume ratio and cognitive function in ischemic leukoaraiosis
10.3760/cma.j.cn115455-20210615-00794
- VernacularTitle:缺血性脑白质疏松症病变体积比率与认知功能的相关性研究
- Author:
Na SUN
1
;
Jianfeng WANG
;
Tianmin GUAN
;
Aiqi WANG
;
Xuemei WANG
;
Lizhen ZHONG
;
Xueying CHENG
;
Hua ZHAO
Author Information
1. 大连医科大学附属大连市中心医院神经内科，大连 116033
- Keywords:
Leukoaraiosis;
Brain ischemia;
Montreal cognitive assessment;
Cognitive impairment
- From:
Chinese Journal of Postgraduates of Medicine
2022;45(1):31-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the volume ratio of ischemic leukoaraiosis (LA) and cognitive level and arterial perfusion.Methods:Fifty-four patients, who was hospitalized in Dalian Central Hospital and diagnosed as LA clinically during the time of March to December in 2012, were selected to collect the information of the volume ratio of white matter disease, MoCa score and the average flow rate of carotid artery. The correlation between the volume ratio of white matter disease and MoCa score, cognitive impairment and the average flow rate of carotid artery were analyzed.Results:The volume ratio of LA lesions was negatively correlated with MOCA score ( r = -0.59, P<0.01); the volume ratio of LA lesions was negatively correlated with the mean flow rate of internal carotid artery ( r = -0.37, P<0.01). Quantity order of the area under receiver operating characteristic (ROC) curve of MoCA cognitive subgroup was as following: delayed memory (1.000)> visual space/executive function (0.970) = abstract force (0.970)> language ability (0.960)> attention (0.888). Conclusions:The larger the volume ratio of leukopathy in LA patients, the more serious the cognitive impairment, especially the cognitive impairment of impairment of memory delay, visual space/executive function, abstract ability and language ability.
