Epidermodysplasia Verruciformis in a patient with Systemic Lupus Erythematosus.
- Author:
Chang Wook KIM
1
;
Moon Seok SHIN
;
Byung Chun KIM
;
Kyu Suk LEE
;
Jun Young SONG
Author Information
1. Department of Dermatology, School of Medicine, Keimyung Medical University, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Epidermodysplasia verruciformis;
EV-specific HPV;
Systemic lupus ereythematosus
- MeSH:
Adult;
Cytoplasm;
Epidermodysplasia Verruciformis*;
Female;
Humans;
Keratinocytes;
Kidney Transplantation;
Lupus Erythematosus, Systemic*;
Papilloma;
Pityriasis;
Prednisolone;
Recurrence;
Shoulder;
Thorax;
Virion;
Warts
- From:Korean Journal of Dermatology
1997;35(6):1203-1207
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Epidermodysplasia verruciformis(EV) is a rare, sometimes familial disorder characterized by chronic infection with EV-specific HPV types. It manifests itself as numerous flat warts, red and brownish macules, and pityriasis versicolor-like lesions. Immunodeficient staies such as AIDS renal transplantation, Hodgkins dis ase, and systemic lupus erythematosus, have been associated with EV. We report a case of a 42-year old female with EV, with lesions on the chest, shoulders, and back, For about the past 2, years, she had been treated with prednisolone for systemic lupus erythematosus. Histopathological findings revealed loose basket-weave-like hyperkeratosis and there were clear large cells arranged in nests in the granular and spinous layers. Their nuclei were shrunken and pyknotic, and the clear cytoplasm was dotted with dispersed keratohyaline granules of different sizes anr shapes. Electron microscopic findings showed aggregates of many viral particles in the nuclei of displastic epidermal keratinocytes. Pan papilloma virus monoclonal Antibody positive nuclei were shown by immunoperoxidase staining. She has been treated with CO, laser and Tretinoin(0.1% ) oin ment. The patient is being monitored for any signs of recurrence for a period of 5months.
