New paradigms of immune regulation in glaucoma during the whole clinical process
10.3760/cma.j.cn115989-20220314-00104
- VernacularTitle:关注免疫炎症调控在青光眼全程诊疗中的作用
- Author:
Jian WU
1
;
Wenru SU
;
Yehong ZHUO
Author Information
1. 中山大学中山眼科中心 眼科学国家重点实验室，广州 510060
- Keywords:
Glaucoma;
Optic nerve injuries;
Retinal ganglion cells;
Immunoregulation
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(4):289-293
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is an irreversible blinding eye disease caused by the structural and functional damage of optic nerve induced by pathological increase of intraocular pressure (IOP), characterized by multiple causes and strong heterogeneity.The control of IOP to reduce the risk of optic damage has been the main therapeutic strategy of glaucoma for many years.However, in clinical experience, some patients show progress of optic nerve damage despite the effectively controlled IOP, the mechanism of non-IOP-dependent secondary damage is still an urgent problem to be solved and a research hotspot in the pathogenesis of glaucoma.With the continuous innovation of molecular biological technology, breakthroughs have been made in the field of basic research.Partial visual recovery can be boosted by alleviating local immune and inflammatory responses.Due to a lack of symbolic clinical application results, it has become an immediate priority to attach importance to the combination of basic clinical research and facilitate the transformation of results.Starting from the theory of glaucoma-immune inflammation, understanding the importance of the immune homeostasis of eyes, paying close attention to the linkage of eyes and brain in physiopathological process and the progression of diseases in the whole visual pathway, and fully understanding and effectively making good use of the opportunities and implications brought by new techniques will have significant effect in formulating clinical diagnosis and treatment plans.
