Familial Systemic Lupus Erythematosus Developed in Two Sisters.
- Author:
Jong Hyuk PARK
1
;
Dae Young CHO
;
Seong Jin KIM
;
Seung Chul LEE
;
Young Ho WON
;
Inn Ki CHUN
Author Information
1. Department of Dermatology, Chonnam University Medical School, Kwangju, Korea.
- Publication Type:Case Report
- Keywords:
Familial;
HLP typing;
Systemic lupus erythematosus
- MeSH:
HLA-A2 Antigen;
Humans;
Lupus Erythematosus, Systemic*;
Siblings*;
Twins, Monozygotic
- From:Korean Journal of Dermatology
1997;35(6):1220-1224
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pathogenesis of systemic lupus erythematosus (SLE) appears to be multifactorial, including both genetic and environmental influences. The genetic factor of SLE is well known to have an important role in the pathogenesis based on epidemiological analysis and studies of monozygotic twins. The disease occur. more commonly in first degree relatives and may affect multiple persons in single families. We report a family in which two sisters developed systernic lupus erythematosus. The clinical, laboratory and histopathological findings showed characteristic features of systemic lupus erythematosus. HLA testing revealed that the two sisters shared common HLA-DR15(2)and HLA-A2.
