Immune factors in the pathogenesis of dacryocystitis and their roles
10.3760/cma.j.cn115989-20191209-00531
- VernacularTitle:泪囊炎发病相关免疫因素及其作用
- Author:
Yue LI
1
;
Caiwen XIAO
Author Information
1. 上海交通大学医学院附属第九人民医院眼科 上海市眼眶病眼肿瘤重点实验室，上海 200011
- Keywords:
Dacryocystitis/etiology;
Immune factors;
Cytokines;
Pathogenesis;
Lacrimal drainage-associated lymphoid tissue
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(2):183-186
- CountryChina
- Language:Chinese
-
Abstract:
Dacryocystitis is a common ophthalmic disease, and the main treatment of it is to abandon the obstructed nasolacrimal duct and create a new lacrimal drainage pathway through implanting a tube.For now, its pathogenesis is understood very limitedly.It is widely accepted that many factors take part in its occurrence, among which obstruction and infection play important roles.Recent researches have shown that there is lacrimal drainage-associated lymphoid tissue (LDALT) which changes remarkably in dacryocystitis, and significant differences in cytokines expression levels in tears between dacryocystitis patients and normal control have been found.In addition, the lacrimal duct has reactions similar to immune rejection to the silicone tube.All of these indicate that immune factors participate in the pathogenesis of dacryocystitis.Changes of immune tissue and macromolecular substances including the LDALT, cytokines, local tissue and cytokines after tube implantation were reviewed to analyze the changes and possible roles of immune factors in the pathogenesis of dacryocystitis.
