NLRP3 inflammasome and its role in age-related macular degeneration
10.3760/cma.j.cn115989-20210922-00527
- VernacularTitle:NLRP3炎症小体在年龄相关性黄斑变性中的作用
- Author:
Lu CHEN
1
;
Ping XIE
;
Zizhong HU
Author Information
1. 南京医科大学第一附属医院眼科 210029
- Keywords:
Macular degeneration;
Inflammasomes;
NLR family, pyrin domain-containing 3 protein;
Retinal pigment epithelium cells;
Interleukin-18;
Interleukin-1β
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD), the leading cause of central vision loss among people aged 50 years and older, is one of the major eye diseases causing blindness in the world.Clinically, advanced AMD is divided into two types, non-exudative AMD with manifestation of geographic atrophy and exudative AMD with manifestation of choroidal neovascularization.The pathogenesis of AMD is complex, and the para-inflammation is recognized as an important risk factor.Nucleotide-binding oligomerization domain like receptors 3 (NLRP3) inflammasome is a cytoplasmic pattern recognition receptor and is expressed in several kings of cells, including retinal pigment epithelium (RPE) cells, microglial cells, Müller glia cells and retinal vascular endothelial cells.Recent studies have suggested that NLRP3 inflammasome plays an important role in the pathophysiology of both non-exudative and exudative AMD.The role of the NLRP3 inflammasome and its effector cytokines interleukin (IL)-1β and IL-18 in AMD were reviewed in this article to provide guidance on future prevention and therapy of AMD.
