The correlation of serum tenascin C level and bronchopulmonary dysplasia comorbid pulmonary hypertension in preterm infants
10.3760/cma.j.issn.2096-2932.2022.03.012
- VernacularTitle:血清肌腱蛋白C水平与早产儿支气管肺发育不良伴肺动脉高压的相关性研究
- Author:
Haiyan ZHU
1
;
Jingjing HU
;
Yafei ZHENG
;
Huaiping CHENG
;
Zhaofang TIAN
Author Information
1. 南京医科大学附属淮安第一医院新生儿科,淮安市小儿呼吸诊疗重点实验室，淮安 223300
- Keywords:
Bronchopulmonary dysplasia;
Hypertension, pulmonary;
Tenascin C;
Infant, premature
- From:Chinese Journal of Neonatology
2022;37(3):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation of serum tenascin C (TNC) and bronchopulmonary dysplasia (BPD) comorbid pulmonary hypertension (PH) in preterm infants.Methods:From January 2017 to June 2020, preterm infants (gestational age<32 weeks) diagnosed of severe BPD admitted to the Neonatal Intensive Care Unit of our hospital were prospectively studied. Comorbidity of PH was evaluated using echocardiography and the infants were assigned into PH (+) group and PH (-) group. At the same time, serum TNC was examined and the correlation between serum TNC level and PH in infants with severe BPD was analyzed.Results:A total of 59 infants with severe BPD were enrolled, including 21 cases comorbid PH (35.6%). The serum TNC level in the PH (+) group was significantly higher than the PH (-) group [(123.7±41.1) ng/ml vs. (78.2±20.2) ng/ml, P<0.05]. Correlation analysis showed a positive correlation between the serum TNC level and systolic pulmonary artery pressure (sPAP) ( r=0.861, P<0.001).The area under the receiver operating characteristic curve of serum TNC predicting BPD comorbid PH was 0.884. The sensitivity and specificity of serum TNC predicting BPD comorbid PH were 84.0% and 76.9% with TNC≥87.7 ng/ml as the cut-off. Conclusions:Severe BPD comorbid PH is common. The serum TNC level in infants with severe BPD comorbid PH is increased and positively correlated with sPAP. The serum TNC level has certain clinical value in predicting and evaluating the severity of BPD comorbid PH.
