Changes and influencing factors of splanchnic regional oxygenation before and after feeding in preterm infants with feeding intolerance
10.3760/cma.j.issn.2096-2932.2022.03.003
- VernacularTitle:喂养不耐受早产儿喂养前后肠道氧合变化及影响因素
- Author:
Qianqian XU
1
;
Guifeng ZHENG
;
Lizhen WANG
;
Shangqin CHEN
;
Zhenlang LIN
Author Information
1. 温州医科大学附属第二医院、育英儿童医院新生儿科，温州 325027
- Keywords:
Feeding intolerance;
Infant,premature;
Splanchnic regional saturation;
Influence factors
- From:Chinese Journal of Neonatology
2022;37(3):203-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the changes and influencing factors of splanchnic regional saturation before and after feeding in preterm infants with feeding intolerance (FI).Methods:From December 2018 to August 2019, preterm infants with FI admitted to the neonatal intensive care unit of our hospital within 24 hours after birth were prospectively enrolled in this same-patient before-after study. Splanchnic regional saturation (rSsO 2) and cerebral regional oxygenation (rSc0 2) 5 minutes before feeding and 1 hour after feeding were monitored using near-infrared spectroscopy (NIRS). The average values of rScO 2, rSsO 2 and splanchnic-cerebral oxygenation ratio (SCOR) before and after feeding were calculated. The clinical data including postnatal age, corrected gestational age and feeding methods (breastfeeding or formula feeding) were collected. Single-factor correlation analysis and multiple linear regression were used to analyze the influencing factors of rSsO 2 before and after feeding. Results:A total of 41 preterm infants were included. No significant differences existed in rSsO 2, rScO 2 and SCOR before and after feeding ( P>0.05). The feeding methods showed relative prominent influences on the changes of rSsO 2 and SCOR before and after feeding. The breastfeeding infants had smaller changes of rSsO 2 and SCOR before and after feeding compared with formula feeding infants, the regression equations were Y=5.538-4.065X (model complex correlation coefficient was 0.414 determination coefficient R2=0.171, F=8.050, P<0.01) and Y=0.109-0.075X (model complex correlation coefficient was 0.405 determination coefficient R=0.1642, F=7.655, P<0.01). Conclusions:Proper feeding will not increase rSsO 2 in preterm infants with FI. Comparing with formula feeding infants, breastfeeding infants has more stable post-feeding rSsO 2.Breastfeeding should be the first choice for preterm infants with FI.
