Total serum bilirubin and bilirubin to albumin values in predicting neonatal acute bilirubin encephalopathy: a multicenter study
10.3760/cma.j.issn.2096-2932.2022.01.007
- VernacularTitle:血清总胆红素和胆红素/白蛋白比值预测新生儿急性胆红素脑病的多中心研究
- Author:
Xiaofan SUN
1
;
Qiufen WEI
;
Zhankui LI
;
Jie GU
;
Jing QIAN
;
Danhua MENG
;
Jinzhen GUO
;
Xiaoli HE
;
Hui NAN
;
Zhangbin YU
;
Shuping HAN
;
Xiaoyue DONG
Author Information
1. 南京医科大学附属妇产医院（南京市妇幼保健院）新生儿科 210004
- Keywords:
Bilirubin encephalopathy,acute;
Hyperbilirubinemia,newborn;
Total serum bilirubin;
The ratio of bilirubin to albumin
- From:Chinese Journal of Neonatology
2022;37(1):25-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the predictive value of total serum bilirubin (TSB) and the ratio of bilirubin to albumin (B/A) in neonatal acute bilirubin encephalopathy (ABE).Methods:Neonates with extremely severe hyperbilirubinemia (TSB≥425 μmol/L) treated in the Nanjing Maternal and Child Health Hospital, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Northwest Women and Children's Hospital, Yinchuan Maternal and Child Health Hospital and Liaocheng People's Hospital from March 2018 to August 2019 were selected as prospective subjects for this study. According to the score of brain injury induced by bilirubin, the subjects were divided into ABE group and non-ABE group, and the predictive value of TSB peak and B/A for neonatal ABE were analyzed.Results:A total of 194 infants with extremely severe hyperbilirubinemia were recruited in this study, including 20 in ABE group and 174 in non-ABE group. The peak value of bilirubin ranged from 427 to 979 μmol/L. The optimal critical values of TSB peak value and B/A for ABE prediction were 530 μmol/L and 9.48, respectively. The sensitivity and specificity of ABE prediction were 85.0% and 92.8% when combined with TSB peak and B/A values.Conclusions:TSB peak combined with B/A value can effectively identify neonatal ABE. When the TSB peak value was greater than 530 μmol/L and the B/A value was greater than 9.48, the neonates had a higher risk of neonatal ABE.
