The incidence and risk factors of periventricular-intraventricular hemorrhage in extremely preterm infants
10.3760/cma.j.issn.2096-2932.2022.01.004
- VernacularTitle:超早产儿脑室周围-脑室内出血发生率及其危险因素分析
- Author:
Bingchun LIN
1
;
Chun CHEN
;
Zhifeng HUANG
;
Chuanzhong YANG
Author Information
1. 南方医科大学附属深圳妇幼保健院新生儿科 518028
- Keywords:
Extremely preterm infant;
Periventricular-intraventricular haemorrhage;
Risk factors
- From:Chinese Journal of Neonatology
2022;37(1):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the incidence and risk factors of periventricular- intraventricular hemorrhage (PIVH) in extremely preterm infants (EPI) with gestational age (GA)<28 weeks.Methods:A retrospective study was performed in 304 cases of EPI hospitalized between January 2016 and December 2018. The infants were assigned into two groups according to whether PIVH occurred. Univariate analysis and Logistic regression analysis were used to determine the risk factors of PIVH.Results:Among the 304 cases,101 (33.2%) developed PIVH and 44 (14.5%) developed severe PIVH.The incidences of PIVH and severe PIVH in EPI with birth weight (BW) <750 g were 50.6% and 31.0%. The incidences of PIVH and severe PIVH in EPI with GA<26 weeks were 51.4% and 27.5%. Logistic regression analysis revealed that advanced GA ( OR=0.697, 95% CI 0.543~0.895, P=0.005) decreased the risk of PIVH. Prolonged invasive mechanical ventilation ( OR=1.121, 95% CI 1.007~1.249, P=0.037) and use of vasoactive drugs ( OR=1.373, 95% CI 1.040~1.812, P=0.025) within the first week of life increased the risk of PIVH. Conclusions:The incidences of PIVH and severe PIVH in EPI are quite high. Smaller GA, longer use of invasive mechanical ventilation and vasoactive drugs within the first week will increase the risk of PIVH in EPI.
