Extended criteria donor reconditioning and functional improvement in the viewshed of machine perfusion plus
10.3760/cma.j.cn115610-20211220-00668
- VernacularTitle:“机械灌注+”视阈下扩大标准供肝的修复与功能提升
- Author:
Kai WANG
1
;
Renyi SU
;
Zhoucheng WANG
;
Xiao XU
Author Information
1. 浙江大学医学院附属杭州市第一人民医院肝胆胰外科，杭州 310006
- Keywords:
General surgery;
Liver transplantation;
Extended criteria donor;
Machine perfusion;
Organ preservation
- From:
Chinese Journal of Digestive Surgery
2022;21(1):74-78
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation (LT) is one of the most effective treatments for end-stage liver diseases. The number of LT in China currently ranks as the second worldwide. Extended criteria donor (ECD) reconditioning and functional improvement is an important research direction at present in order to address the bottleneck of donor graft shortage. In the future, it is pivotal to explore the original breakthroughs in basic theories of stem cell fates regulation, organ restoration and tissue regeneration, and to conduct national-wide, multicenter clinical investigations on the basis of innovative platform of medical, engineering and information technology. Therefore, the authors summarize evidence-based medical proof, latest research achievements and clinical experi-ences with novel concept of "machine perfusion plus" to explore the most updated mode that inte-grates traditional machine perfusion with cutting edge technologies such as multi-omics, molecular biology, information technology, automation technology and nanoparticle targeted delivery tech-nology. This aims to achieve real-time, non-invasive, intelligent quality assessment and monitoring of donor graft, and finally to establish a new technology system of ECD reconditioning and functional improvement, which can safely and effectively expand the donor pool, decrease the risk of post-transplant complications, and improve the prognosis of recipients, thus promoting the higher quality development of LT in China.
