Clinical efficacy of hepatic artery infusion chemotherapy combined with immunotherapy plus target therapy in the treatment of advanced hepatocellular carcinoma
10.3760/cma.j.cn115610-20210630-00324
- VernacularTitle:肝动脉灌注化疗联合免疫靶向治疗晚期肝细胞癌的临床疗效
- Author:
Song CHEN
1
;
Wenbo GUO
;
Zhiqiang WU
;
Wenquan ZHUANG
;
Hongjie CAI
;
Fan WANG
Author Information
1. 中山大学附属第一医院放射介入科，广州 510080
- Keywords:
Liver neoplasms;
Attilizumab;
Bevacizumab;
Intervetion;
Combination therapy
- From:
Chinese Journal of Digestive Surgery
2021;20(S2):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and the new cases of HCC in China account for more than half of the global cases every year. High incidence mortality and limited treatment methods are the main challen-ges for HCC prevention and treatment in China. Immunotherapy has brought new treatment options and hope of prolonging the survival to patients with advanced HCC. Data from the IMbrave 150 study published in the New England Journal of Medicine in May 2020 showed that the median overall survival of all patients was 19.2 months, and the median overall survival of the Chinese subgroup was 24.0 months, which suggested significant efficacy in prolongating patient survival and controlling tumor. Interven-tional therapy has been playing an important role in the treatment of HCC, and more and more clinical studies have adopted systematic therapy combined with interventional therapy. Interven-tional therapy and systematic therapy have synergistic efficacy which lead to significant clinical efficacy. The authors introduce the diagnosis and treatment of an advanced HCC patient undergoing interventional therapy combined with bevacizumab plus attilizumab treatment, which lead to signifi-cant clinical efficacy of tumor controlling.
