Qualitative study of the Chimeric antigen receptor T cells therapy decision-making process for caregivers of children with hematologic malignancies
10.3760/cma.j.cn211501-20210322-00861
- VernacularTitle:嵌合抗原受体T细胞治疗血液系统肿瘤患儿照顾者决策过程心理体验的质性研究
- Author:
Guanxun ZHANG
1
;
Yuying SHAN
;
Rongrong LI
;
Qi YANG
;
Xinyi SHEN
Author Information
1. 苏州大学附属儿童医院血液科，苏州 215025
- Keywords:
Chimeric antigen receptors;
Clinical trial;
Hematologic malignancy;
Child;
Caregiver;
Decision-making experience
- From:
Chinese Journal of Practical Nursing
2022;38(11):863-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the inner experience and influencing factors of caregivers′ decision-making process in children with hematological tumors treated by Chimeric antigen receptor T cells (CAR-T) cell clinical trial, so as to provide reference for children and caregivers treated with CAR-T cells to carry out targeted health education and psychological support.Methods:Using the phenomenological method of qualitative study, the caregivers of 11 children were interviewed by semi-structured interview, the data were analyzed by Colaizzi analysis method, and the text data were managed, explored and searched by NVivo10.0 software.Results:The caregivers of children with hematological tumors had three topics: complex psychological experience in the initial stage of CAR-T treatment decision-making process, consultation approach and experience in the decision-making process, and overall decision-making quality evaluation.Conclusions:Pay attention to and understand the psychological experience of caregivers in CAR-T cell clinical trials, provide diversified decision-making counseling for caregivers, and ensure the right of caregivers to participate in decision-making, so as to improve caregivers′ treatment and nursing compliance.
