Research progress of interleukin-17 in offspring autism spectrum disorder

VernacularTitle:白细胞介素-17在子代孤独症谱系障碍中的相关研究进展
Author: Yanmei ZENG ¹ ; Yuxia CUI
Author Information

1. 贵州医科大学临床医学院，贵阳　550004
Keywords: Interleukin-17; Autism spectrum disorder; Maternal immune activation
From: Chinese Journal of Applied Clinical Pediatrics 2022;37(9):718-720
CountryChina
Language:Chinese
Abstract: Interleukin-17 (IL-17) plays an important role in the body′s immune response and inflammatory response.High levels of IL-17 are associated with a variety of autoimmune diseases, acute and chronic neurodegenerative diseases, and psychiatric disorders.Autism spectrum disorder (ASD) is a group of common neurodevelopmental disorders in childhood.Recent clinical and experimental studies have linked maternal immune activation (MIA) during pregnancy to the risk of ASD in offspring.Significantly increased IL-17 level is found in MIA-induced progeny ASD, which is the key factor leading to neurodevelopmental abnormalities in progeny mice.This article reviews the latest research progress on the relationship between IL-17 and progeny ASD, and provides new ideas for the prevention and treatment of ASD.