Progress of diagnosis and treatment of penicillium marneffei infection in children
10.3760/cma.j.cn101070-20201014-01619
- VernacularTitle:儿童马尔尼菲青霉菌感染的诊治进展
- Author:
Xuehua XU
1
;
Huifeng FAN
;
Gen LU
Author Information
1. 广州医科大学附属广州市妇女儿童医疗中心呼吸科，广州 510623
- Keywords:
Child;
Penicillium marneffei;
Diagnosis;
Treatment
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(6):474-477
- CountryChina
- Language:Chinese
-
Abstract:
Penicillium marneffei (PM) is the only thermally dimorphic species as a Penicillium that causes the transmitted penicilliosis marneffei (PSM). PM infection is more common in immunodeficient children.Due to the lack of specific clinical manifestations, PSM is easily misdiagnosed as pulmonary plasmacycosis, tuberculosis or pulmonary aspergillosis.Because of the rapid progress and multiple complications of transmitted PSM, its mortality remains high without timely and effective treatment.Therefore, early diagnosis and treatment are of great significance, and the diagnosis of PSM mainly relies on the immune function examination, measurement of serum markers, pathogen detection and imaging examinations.There is no standard antifungal regimen, and Amphoterus B and Itraconazole are used as the first-line treatment.This study aims to review the progress of diagnosis and treatment of PM infection in children.
