Clinical efficacy of intra-articular injection with Triamcinolone acetonide in patients with juvenile idiopathic arthritis
10.3760/cma.j.cn101070-20201104-01720
- VernacularTitle:曲安奈德关节腔内注射治疗幼年特发性关节炎的临床疗效
- Author:
Ying CHI
1
;
Jianming LAI
;
Zhixuan ZHOU
;
Gaixiu SU
;
Min KANG
;
Shengnan LI
;
Dan ZHANG
;
Li′nan MA
Author Information
1. 首都儿科研究所附属儿童医院风湿免疫科，北京 100020
- Keywords:
Triamcinolone acetonide;
Juvenile rheumatoid arthritis;
Intra-articular injection
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(6):421-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of intra-articular injection with Triamcinolone acetonide on the treatment of juvenile idiopathic arthritis (JIA).Methods:The clinical data of 26 children diagnosed with JIA undergoing the intra-articular injection of Triamcinolone acetonide for the joints with obvious swelling and pain at the Children′s Hospital Affiliated to Capital Institute of Pediatrics from October 2018 to December 2019 who were retrospectively analyzed.Erythrocyte sedimentation rate (ESR) and C-reactive protein(CRP) were tested before and after the application of Triamcinolone acetonide.Detailed clinical manifestations were recorded.The nonparametric Kruskal- Wallis test was used to compare the differences in clinical evaluation indicators and changes in laboratory tests at diffe-rent treatment times. Results:Among the 26 children, 8 were boys and 18 were girls.After the intra-articular injection of Triamcinolone acetonide, 9 cases (34.62%) achieved complete remission, 15 cases(57.69%) achieved partial remission, and 2 cases (7.69%) were not responsive to the intra-articular injection.The overall therapeutic efficacy was 92.31%.Compared with pre-treatment period, from 4 weeks after treatment, assessment of disease activity by the physicians and parents of the children was significantly improved after 4-week treatment, and the number of active joints, ESR and CRP and the Juvenile Arthritis Disease Activity Score with 27 joints (JADAS 27) gradually decreased, and the differences were statistically significant (all P<0.05). No adverse drug reactions were seen during the treatment and follow-up period. Conclusions:Intra-articular injection of Triamcinolone acetonide is effective in contro-lling joint symptoms of JIA with less adverse events.
