Successful treatment of CD 19 targeted chimeric antigen receptor T cells in 2 children with isolated testicular recurrence of acute B lymphoblastic leukemia and literature review
10.3760/cma.j.cn101070-20201119-01781
- VernacularTitle:CD 19靶向的嵌合抗原受体T细胞治疗儿童急性B淋巴细胞白血病孤立性睾丸复发2例及文献复习
- Author:
Qiyu YANG
1
;
Jun LU
;
Zong ZHAI
;
Guanghua CHEN
;
Shaoyan HU
;
Ye LU
;
Tiandan LI
;
Mengmeng DING
;
Yi WANG
Author Information
1. 苏州大学附属儿童医院血液肿瘤科，苏州 215000
- Keywords:
Child;
CD 19 targeted chimeric antigen receptor T cells;
Isolated testicular recurrence;
Extramedu-llary recurrence
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(5):382-385
- CountryChina
- Language:Chinese
-
Abstract:
This study reports the diagnosis and treatment of 2 children with isolated testicular recurrence (ITR) of acute B lymphoblastic leukemia (B-ALL) treated with CD 19 targeted chimeric antigen receptor T (CD 19 CAR-T) cells in May and December 2019 in the Department of Hematology and Oncology, Children′s Hospital of Soochow University, and explores the efficacy of CD 19 CAR-T cells therapy versus conventional radiotherapy and chemotherapy through literature review.Both cases were diagnosed as B-ALL by the morphologic, immunologic, cytogenetic and molecular biology methods.ITR was diagnosed by testicular biopsy at 60 months and 38 months after initial diagnosis in 2 cases, respectively.After infusion of CD 19 CAR-T cells at 7.0×10 6/kg and 1.5×10 7/kg, respectively for 7-10 days, testicular leukemia cell infiltration disappeared and complete remission was obtained.Among them, case 2 developed cytokine release syndrome and immune effector cell-related neurotoxicity syndrome after treatment, which was improved after drug intervention.It is suggested that CD 19 CAR-T cells are effective in the treatment of ITR in children, which may be an alternative to orchiectomy or local radiotherapy for ITR in children with B-ALL.
